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Phase II Study of Intermediate-Dose Cytarabine in Patients with Relapsed or Refractory Ewing Sarcoma: A Report from the Children's Oncology Group

BACKGROUND: Patients with relapsed or refractory Ewing sarcoma have a poor outcome with conventional therapies. Cytarabine decreases EWS/FLI1 protein levels in Ewing sarcoma cells and has demonstrated preclinical activity against Ewing sarcoma in vitro and in vivo. The purpose of this phase II clini...

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Detalhes bibliográficos
Main Authors: DuBois, Steven G., Krailo, Mark D., Lessnick, Stephen L., Smith, Richard, Chen, Zhengjia, Marina, Neyssa, Grier, Holcombe E., Stegmaier, Kimberly
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791370/
https://ncbi.nlm.nih.gov/pubmed/18989890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.21822
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