Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group

BACKGROUND: New prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy. We describe the incidence and association with outcome of circulating tumour DNA (ctDNA) using next-generation sequencing (NGS) assays. METHODS: A N...

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Publicat a:Br J Cancer
Autors principals: Shulman, David S., Klega, Kelly, Imamovic-Tuco, Alma, Clapp, Andrea, Nag, Anwesha, Thorner, Aaron R., Van Allen, Eliezer, Ha, Gavin, Lessnick, Stephen L., Gorlick, Richard, Janeway, Katherine A., Leavey, Patrick J., Mascarenhas, Leo, London, Wendy B., Vo, Kieuhoa T., Stegmaier, Kimberly, Hall, David, Krailo, Mark D., Barkauskas, Donald A., DuBois, Steven G., Crompton, Brian D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162271/
https://ncbi.nlm.nih.gov/pubmed/30131550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0212-9
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