Microbial Dysbiosis Associated with Impaired Intestinal Na(+)/H(+) Exchange Accelerates and Exacerbates Colitis in Ex-Germ Free Mice

Intestinal epithelial Na(+)/H(+) exchange facilitated by the apical NHE3 (Slc9a3) is a highly-regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3(−/−) mice develop spontaneous, bacterially-mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na(...

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Udgivet i:Mucosal Immunol
Main Authors: Harrison, Christy A., Laubitz, Daniel, Ohland, Christina L., Midura-Kiela, Monica T., Patil, Karuna, Besselsen, David G., Jamwal, Deepa R., Jobin, Christian, Ghishan, Fayez K., Kiela, Pawel R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162102/
https://ncbi.nlm.nih.gov/pubmed/29875400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-018-0035-2
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