Reduced Epithelial Na(+)/H(+) Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis

Inflammatory bowel diseases (IBD) are associated with functional inhibition of epithelial Na(+)/H(+) exchange. In mice, a selective disruption of NHE3 (Slc9a3), a major apical Na(+)/H(+) exchanger, also promotes IBD-like symptoms and gut microbial dysbiosis. We hypothesized that disruption of Na(+)/...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Laubitz, Daniel, Harrison, Christy A., Midura-Kiela, Monica T., Ramalingam, Rajalakshmy, Larmonier, Claire B., Chase, John H., Caporaso, J. Gregory, Besselsen, David G., Ghishan, Fayez K., Kiela, Pawel R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822813/
https://ncbi.nlm.nih.gov/pubmed/27050757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152044
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items