Reduced Epithelial Na(+)/H(+) Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis

Inflammatory bowel diseases (IBD) are associated with functional inhibition of epithelial Na(+)/H(+) exchange. In mice, a selective disruption of NHE3 (Slc9a3), a major apical Na(+)/H(+) exchanger, also promotes IBD-like symptoms and gut microbial dysbiosis. We hypothesized that disruption of Na(+)/...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Laubitz, Daniel, Harrison, Christy A., Midura-Kiela, Monica T., Ramalingam, Rajalakshmy, Larmonier, Claire B., Chase, John H., Caporaso, J. Gregory, Besselsen, David G., Ghishan, Fayez K., Kiela, Pawel R.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822813/
https://ncbi.nlm.nih.gov/pubmed/27050757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152044
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