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Microbial Dysbiosis Associated with Impaired Intestinal Na(+)/H(+) Exchange Accelerates and Exacerbates Colitis in Ex-Germ Free Mice
Intestinal epithelial Na(+)/H(+) exchange facilitated by the apical NHE3 (Slc9a3) is a highly-regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3(−/−) mice develop spontaneous, bacterially-mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na(...
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| 出版年: | Mucosal Immunol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6162102/ https://ncbi.nlm.nih.gov/pubmed/29875400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-018-0035-2 |
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