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Reduced Epithelial Na(+)/H(+) Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis

Inflammatory bowel diseases (IBD) are associated with functional inhibition of epithelial Na(+)/H(+) exchange. In mice, a selective disruption of NHE3 (Slc9a3), a major apical Na(+)/H(+) exchanger, also promotes IBD-like symptoms and gut microbial dysbiosis. We hypothesized that disruption of Na(+)/...

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發表在:	PLoS One
Main Authors:	Laubitz, Daniel, Harrison, Christy A., Midura-Kiela, Monica T., Ramalingam, Rajalakshmy, Larmonier, Claire B., Chase, John H., Caporaso, J. Gregory, Besselsen, David G., Ghishan, Fayez K., Kiela, Pawel R.
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science 2016
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4822813/ https://ncbi.nlm.nih.gov/pubmed/27050757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152044
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Reduced Epithelial Na(+)/H(+) Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis

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