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Nanoscale inhibition of polymorphic and ambidextrous IAPP amyloid aggregation with small molecules

Understanding how small molecules interface amyloid fibrils on the nanoscale is of importance for developing therapeutic treatment against amyloid-based diseases. Here we show, for the first time, that human islet amyloid polypeptide (IAPP) in the fibrillar form is polymorphic and ambidextrous posse...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nano Res
Prif Awduron: Kakinen, Aleksandr, Adamcik, Jozef, Wang, Bo, Ge, Xinwei, Mezzenga, Raffaele, Davis, Thomas P., Ding, Feng, Ke, Pu Chun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162064/
https://ncbi.nlm.nih.gov/pubmed/30275931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12274-017-1930-7
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