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Amorphous Nanosuspensions Aggregated from Paclitaxel–Hemoglobulin Complexes with Enhanced Cytotoxicity

Amorphous nanosuspensions (ANSs) enable rapid release and improved delivery of a poorly water-soluble drug; however, their preparation is challenging. Here, using hemoglobin (Hb) as a carrier, ANSs aggregated from paclitaxel (PTX)–Hb complexes were prepared to improve delivery of the hydrophobic ant...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Pharmaceutics
Hauptverfasser: Qin, Chao, Xin, Xiaofei, Pei, Xue, Yin, Lifang, He, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161098/
https://ncbi.nlm.nih.gov/pubmed/30011808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10030092
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