Paclitaxel Enhances Carboplatin-DNA Adduct Formation and Cytotoxicity

This rapid report focuses on the pharmacodynamic mechanism of the carboplatin/paclitaxel combination and correlates it with its cytotoxicity. Consistent with the synergistic to additive antitumor activity (the combination index ranging from 0.53 to 0.94), cells exposed to this combination had signif...

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Pubblicato in:Chem Res Toxicol
Autori principali: Jiang, Shuai, Pan, Amy W., Lin, Tzu-yin, Zhang, Hongyong, Malfatti, Michael, Turteltaub, Kenneth, Henderson, Paul T., Pan, Chong-xian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834887/
https://ncbi.nlm.nih.gov/pubmed/26544157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.5b00422
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