Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling. Abnormal activation of Notch signaling and defective repair of DSBs promote breast cancer risk. Here, we found that low expressio...

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發表在:J Clin Invest
Main Authors: Li, Li, Guturi, Kiran Kumar Naidu, Gautreau, Brandon, Patel, Parasvi S., Saad, Amine, Morii, Mayako, Mateo, Francesca, Palomero, Luis, Barbour, Haithem, Gomez, Antonio, Ng, Deborah, Kotlyar, Max, Pastrello, Chiara, Jackson, Hartland W., Khokha, Rama, Jurisica, Igor, Affar, El Bachir, Raught, Brian, Sanchez, Otto, Alaoui-Jamali, Moulay, Pujana, Miguel A., Hakem, Anne, Hakem, Razq
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160000/
https://ncbi.nlm.nih.gov/pubmed/30222135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120401
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