Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling. Abnormal activation of Notch signaling and defective repair of DSBs promote breast cancer risk. Here, we found that low expressio...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Li, Li, Guturi, Kiran Kumar Naidu, Gautreau, Brandon, Patel, Parasvi S., Saad, Amine, Morii, Mayako, Mateo, Francesca, Palomero, Luis, Barbour, Haithem, Gomez, Antonio, Ng, Deborah, Kotlyar, Max, Pastrello, Chiara, Jackson, Hartland W., Khokha, Rama, Jurisica, Igor, Affar, El Bachir, Raught, Brian, Sanchez, Otto, Alaoui-Jamali, Moulay, Pujana, Miguel A., Hakem, Anne, Hakem, Razq
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160000/
https://ncbi.nlm.nih.gov/pubmed/30222135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120401
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