Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer

Tumor relapse is the leading cause of death in breast cancer, largely due to the fact that recurrent tumors are frequently resistant to chemotherapy. We previously reported that downregulation of the proapoptotic protein Par-4 promotes tumor recurrence in genetically engineered mouse models of breas...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Mabe, Nathaniel W., Fox, Douglas B., Lupo, Ryan, Decker, Amy E., Phelps, Stephanie N., Thompson, J. Will, Alvarez, James V.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159989/
https://ncbi.nlm.nih.gov/pubmed/30148456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99481
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