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Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer

Tumor relapse is the leading cause of death in breast cancer, largely due to the fact that recurrent tumors are frequently resistant to chemotherapy. We previously reported that downregulation of the proapoptotic protein Par-4 promotes tumor recurrence in genetically engineered mouse models of breas...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Mabe, Nathaniel W., Fox, Douglas B., Lupo, Ryan, Decker, Amy E., Phelps, Stephanie N., Thompson, J. Will, Alvarez, James V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159989/
https://ncbi.nlm.nih.gov/pubmed/30148456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99481
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