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Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer
Tumor relapse is the leading cause of death in breast cancer, largely due to the fact that recurrent tumors are frequently resistant to chemotherapy. We previously reported that downregulation of the proapoptotic protein Par-4 promotes tumor recurrence in genetically engineered mouse models of breas...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6159989/ https://ncbi.nlm.nih.gov/pubmed/30148456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99481 |
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