Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth

The paracaspase MALT1 plays an essential role in activated B cell–like diffuse large B cell lymphoma (ABC DLBCL) downstream of B cell and TLR pathway genes mutated in these tumors. Although MALT1 is considered a compelling therapeutic target, the development of tractable and specific MALT1 protease...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Fontán, Lorena, Qiao, Qi, Hatcher, John M., Casalena, Gabriella, Us, Ilkay, Teater, Matt, Durant, Matt, Du, Guangyan, Xia, Min, Bilchuk, Natalia, Chennamadhavuni, Spandan, Palladino, Giuseppe, Inghirami, Giorgio, Philippar, Ulrike, Wu, Hao, Scott, David A., Gray, Nathanael S., Melnick, Ari
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159983/
https://ncbi.nlm.nih.gov/pubmed/30024860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99436
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