Identification of MALT1 feedback mechanisms enables rational design of potent antilymphoma regimens for ABC-DLBCL

MALT1 inhibitors are promising therapeutic agents for B-cell lymphomas that are dependent on constitutive or aberrant signaling pathways. However, a potential limitation for signal transduction–targeted therapies is the occurrence of feedback mechanisms that enable escape from the full impact of suc...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Fontan, Lorena, Goldstein, Rebecca, Casalena, Gabriella, Durant, Matthew, Teater, Matthew R., Wilson, Jimmy, Phillip, Jude, Xia, Min, Shah, Shivem, Us, Ilkay, Shinglot, Himaly, Singh, Ankur, Inghirami, Giorgio, Melnick, Ari
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2021
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7885826/
https://ncbi.nlm.nih.gov/pubmed/32785655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004713
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