MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. We developed a MALT1 activity assay and identified chemically diverse MALT1 inhibitors. A selected lead compound, MI-2, featured direct binding to...

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Detalhes bibliográficos
Main Authors: Fontan, Lorena, Yang, Chenghua, Kabaleeswaran, Venkataraman, Volpon, Laurent, Osborne, Michael J., Beltran, Elena, Garcia, Monica, Cerchietti, Leandro, Shaknovich, Rita, Yang, Shao Ning, Fang, Fang, Gascoyne, Randy D., Martinez-Climent, Jose Angel, Glickman, J. Fraser, Borden, Katherine, Wu, Hao, Melnick, Ari
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984478/
https://ncbi.nlm.nih.gov/pubmed/23238016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.11.003
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