Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth

The paracaspase MALT1 plays an essential role in activated B cell–like diffuse large B cell lymphoma (ABC DLBCL) downstream of B cell and TLR pathway genes mutated in these tumors. Although MALT1 is considered a compelling therapeutic target, the development of tractable and specific MALT1 protease...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Fontán, Lorena, Qiao, Qi, Hatcher, John M., Casalena, Gabriella, Us, Ilkay, Teater, Matt, Durant, Matt, Du, Guangyan, Xia, Min, Bilchuk, Natalia, Chennamadhavuni, Spandan, Palladino, Giuseppe, Inghirami, Giorgio, Philippar, Ulrike, Wu, Hao, Scott, David A., Gray, Nathanael S., Melnick, Ari
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159983/
https://ncbi.nlm.nih.gov/pubmed/30024860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99436
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados