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Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation
Supplementation with high doses of folic acid, an important mediator of one-carbon transfers for DNA methylation, is used clinically to improve sperm parameters in infertile men. We recently detected an unexpected loss of DNA methylation in the sperm of idiopathic infertile men after 6 months of dai...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6159534/ https://ncbi.nlm.nih.gov/pubmed/29360980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy021 |
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