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Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency

Valproate (VPA) treatment in pregnancy leads to congenital anomalies, possibly by disrupting folate or homocysteine metabolism. Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate interconversion and homocysteine metabolism, we addressed the possibility that VPA might have di...

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Bibliografiske detaljer
Main Authors: Roy, Marc, Leclerc, Daniel, Wu, Qing, Gupta, Sapna, Kruger, Warren D., Rozen, Rima
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574752/
https://ncbi.nlm.nih.gov/pubmed/18615588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.21847
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