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Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency

Valproate (VPA) treatment in pregnancy leads to congenital anomalies, possibly by disrupting folate or homocysteine metabolism. Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate interconversion and homocysteine metabolism, we addressed the possibility that VPA might have di...

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Main Authors: Roy, Marc, Leclerc, Daniel, Wu, Qing, Gupta, Sapna, Kruger, Warren D., Rozen, Rima
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574752/
https://ncbi.nlm.nih.gov/pubmed/18615588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.21847
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