Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency

MTHFR (methylenetetrahydrofolate reductase) catalyses the synthesis of 5-methyltetrahydrofolate, the folate derivative utilized in homocysteine remethylation to methionine. A severe deficiency of MTHFR results in hyperhomocysteinaemia and homocystinuria. Betaine supplementation has proven effective...

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Autori principali: Schwahn, Bernd C., Laryea, Maurice D., Chen, Zhoutao, Melnyk, Stepan, Pogribny, Igor, Garrow, Timothy, James, S. Jill, Rozen, Rima
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2004
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133958/
https://ncbi.nlm.nih.gov/pubmed/15217352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030822
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