Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder of which the progression is influenced by several disease-modifying factors. Here, we investigated ELP3, a subunit of the elongator complex that modifies tRNA wobble uridines, as one of such ALS disease modifiers. ELP3...

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Publicat a:Hum Mol Genet
Autors principals: Bento-Abreu, Andre, Jager, Gunilla, Swinnen, Bart, Rué, Laura, Hendrickx, Stijn, Jones, Ashley, Staats, Kim A, Taes, Ines, Eykens, Caroline, Nonneman, Annelies, Nuyts, Rik, Timmers, Mieke, Silva, Lara, Chariot, Alain, Nguyen, Laurent, Ravits, John, Lemmens, Robin, Cabooter, Deirdre, Van Den Bosch, Ludo, Van Damme, Philip, Al-Chalabi, Ammar, Bystrom, Anders, Robberecht, Wim
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159532/
https://ncbi.nlm.nih.gov/pubmed/29415125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy043
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