Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1(G93A) mice

Oligodendrocytes are essential for structural and trophic support of motor axons. Their impairment has been implicated in amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder of motor neurons. Oligodendrocyte progenitor cells fail to differentiate into mature oligodendrocytes and thereb...

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Pubblicato in:Neurobiol Aging
Autori principali: Eykens, Caroline, Nonneman, Annelies, Jensen, Cathy, Iavarone, Antonio, Van Damme, Philip, Van Den Bosch, Ludo, Robberecht, Wim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998381/
https://ncbi.nlm.nih.gov/pubmed/29689424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.03.026
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