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Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder of which the progression is influenced by several disease-modifying factors. Here, we investigated ELP3, a subunit of the elongator complex that modifies tRNA wobble uridines, as one of such ALS disease modifiers. ELP3...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Bento-Abreu, Andre, Jager, Gunilla, Swinnen, Bart, Rué, Laura, Hendrickx, Stijn, Jones, Ashley, Staats, Kim A, Taes, Ines, Eykens, Caroline, Nonneman, Annelies, Nuyts, Rik, Timmers, Mieke, Silva, Lara, Chariot, Alain, Nguyen, Laurent, Ravits, John, Lemmens, Robin, Cabooter, Deirdre, Van Den Bosch, Ludo, Van Damme, Philip, Al-Chalabi, Ammar, Bystrom, Anders, Robberecht, Wim
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159532/
https://ncbi.nlm.nih.gov/pubmed/29415125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy043
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