Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

BACKGROUND: WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in chondrogenesis and cartilage degeneration. METHODS: Exosomal miR-92a-3p expression was assessed in vitro in a human mesenchymal stem ce...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Mao, Guping, Zhang, Ziji, Hu, Shu, Zhang, Zhiqi, Chang, Zongkun, Huang, Zhiyu, Liao, Weiming, Kang, Yan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158854/
https://ncbi.nlm.nih.gov/pubmed/30257711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-1004-0
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