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Inhibiting Epidermal Growth Factor Receptor Dimerization and Signaling Through Targeted Delivery of a Juxtamembrane Domain Peptide Mimic

Overexpression and deregulation of the epidermal growth factor receptor (EGFR) are implicated in multiple human cancers and therefore are a focus for the development of therapeutics. Current strategies aimed at inhibiting EGFR activity include monoclonal antibodies and tyrosine kinase inhibitors. Ho...

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Detalles Bibliográficos
Publicado en:ACS Chem Biol
Main Authors: Gerhart, Janessa, Thévenin, Anastasia F., Bloch, Elizabeth, King, Kelly E., Thévenin, Damien
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158778/
https://ncbi.nlm.nih.gov/pubmed/30133245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00555
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