TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

The Artemis nuclease and tyrosyl-DNA phosphodiesterase (TDP1) are each capable of resolving protruding 3′-phosphoglycolate (PG) termini of DNA double-strand breaks (DSBs). Consequently, both a knockout of Artemis and a knockout/knockdown of TDP1 rendered cells sensitive to the radiomimetic agent neo...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Kawale, Ajinkya S, Akopiants, Konstantin, Valerie, Kristoffer, Ruis, Brian, Hendrickson, Eric A, Huang, Shar-yin N, Pommier, Yves, Povirk, Lawrence F
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158748/
https://ncbi.nlm.nih.gov/pubmed/30113698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky694
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