Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries

Nucleic acid aptamers, especially RNA, exhibit valuable advantages compared to protein therapeutics in terms of size, affinity and specificity. However, the synthesis of libraries of large random RNAs is still difficult and expensive. The engineering of polymerases able to directly generate these li...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Randrianjatovo-Gbalou, Irina, Rosario, Sandrine, Sismeiro, Odile, Varet, Hugo, Legendre, Rachel, Coppée, Jean-Yves, Huteau, Valérie, Pochet, Sylvie, Delarue, Marc
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Nucleic Acid Enzymes
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158600/
https://ncbi.nlm.nih.gov/pubmed/29788485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky413
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