Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries

Nucleic acid aptamers, especially RNA, exhibit valuable advantages compared to protein therapeutics in terms of size, affinity and specificity. However, the synthesis of libraries of large random RNAs is still difficult and expensive. The engineering of polymerases able to directly generate these li...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Randrianjatovo-Gbalou, Irina, Rosario, Sandrine, Sismeiro, Odile, Varet, Hugo, Legendre, Rachel, Coppée, Jean-Yves, Huteau, Valérie, Pochet, Sylvie, Delarue, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158600/
https://ncbi.nlm.nih.gov/pubmed/29788485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky413
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