Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries

Nucleic acid aptamers, especially RNA, exhibit valuable advantages compared to protein therapeutics in terms of size, affinity and specificity. However, the synthesis of libraries of large random RNAs is still difficult and expensive. The engineering of polymerases able to directly generate these li...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Randrianjatovo-Gbalou, Irina, Rosario, Sandrine, Sismeiro, Odile, Varet, Hugo, Legendre, Rachel, Coppée, Jean-Yves, Huteau, Valérie, Pochet, Sylvie, Delarue, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158600/
https://ncbi.nlm.nih.gov/pubmed/29788485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky413
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