Herpes Simplex Virus 1 γ(1)34.5 Protein Inhibits STING Activation That Restricts Viral Replication

The γ(1)34.5 gene of herpes simplex virus 1 (HSV-1) encodes a virulence factor that promotes viral pathogenesis. Although it perturbs TANK-binding kinase 1 (TBK1) in the complex network of innate immune pathways, the underlying mechanism is obscure. Here we report that HSV-1 γ(1)34.5 targets stimula...

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Bibliographic Details
Published in:J Virol
Main Authors: Pan, Shuang, Liu, Xing, Ma, Yijie, Cao, Youjia, He, Bin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158424/
https://ncbi.nlm.nih.gov/pubmed/30045990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01015-18
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