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Metabolic Labeling of Prenylated Proteins Using Alkyne-Modified Isoprenoid Analogues

Protein prenylation involves the attachment of a farnesyl or geranylgeranyl group onto a cysteine residue located near the C-terminus of a protein, recognized via a specific prenylation motif and results in the formation of a thioether bond. To identify putative prenylated proteins and investigate c...

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Detalhes bibliográficos
Publicado no:Curr Protoc Chem Biol
Main Authors: Suazo, Kiall F., Hurben, Alexander K., Liu, Kevin, Xu, Feng, Thao, Pa, Sudheer, Ch., Li, Ling, Distefano, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158066/
https://ncbi.nlm.nih.gov/pubmed/30058775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpch.46
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