Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells

[Image: see text] Protein prenylation is a post-translational modification that is responsible for membrane association and protein–protein interactions. The oncogenic protein Ras, which is prenylated, has been the subject of intense study in the past 20 years as a therapeutic target. Several studie...

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Publicat a:ACS Chem Biol
Autors principals: Palsuledesai, Charuta C., Ochocki, Joshua D., Kuhns, Michelle M., Wang, Yen-Chih, Warmka, Janel K., Chernick, Dustin S., Wattenberg, Elizabeth V., Li, Ling, Arriaga, Edgar A., Distefano, Mark D.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074897/
https://ncbi.nlm.nih.gov/pubmed/27525511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00421
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