Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells

[Image: see text] Protein prenylation is a post-translational modification that is responsible for membrane association and protein–protein interactions. The oncogenic protein Ras, which is prenylated, has been the subject of intense study in the past 20 years as a therapeutic target. Several studie...

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Publicado no:ACS Chem Biol
Main Authors: Palsuledesai, Charuta C., Ochocki, Joshua D., Kuhns, Michelle M., Wang, Yen-Chih, Warmka, Janel K., Chernick, Dustin S., Wattenberg, Elizabeth V., Li, Ling, Arriaga, Edgar A., Distefano, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074897/
https://ncbi.nlm.nih.gov/pubmed/27525511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00421
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