Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis

Chemokine synergy-inducing molecules are emerging as regulating factors in cell migration. The alarmin HMGB1, in its reduced form, can complex with CXCL12 enhancing its activity on monocytes via the chemokine receptor CXCR4, while the form containing a disulfide bond, by binding to TLR2 or TLR4, ini...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Cecchinato, Valentina, D'Agostino, Gianluca, Raeli, Lorenzo, Nerviani, Alessandra, Schiraldi, Milena, Danelon, Gabriela, Manzo, Antonio, Thelen, Marcus, Ciurea, Adrian, Bianchi, Marco E., Rubartelli, Anna, Pitzalis, Costantino, Uguccioni, Mariagrazia
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157448/
https://ncbi.nlm.nih.gov/pubmed/30283452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02118
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