Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate

Aims: We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing H(2)O(2) and utilizing it subsequently in protein S-glutathionylation in a glutathione peroxidase (GPx)-like manner. In...

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Vydáno v:Antioxid Redox Signal
Hlavní autoři: Tovmasyan, Artak, Bueno-Janice, Jacqueline C., Jaramillo, Melba C., Sampaio, Romulo S., Reboucas, Julio S., Kyui, Natalia, Benov, Ludmil, Deng, Brian, Huang, Ting-Ting, Tome, Margaret E., Spasojevic, Ivan, Batinic-Haberle, Ines
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc., publishers 2018
Témata:
Forum Original Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157436/
https://ncbi.nlm.nih.gov/pubmed/29390861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2017.7218
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