Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate

Aims: We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing H(2)O(2) and utilizing it subsequently in protein S-glutathionylation in a glutathione peroxidase (GPx)-like manner. In...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Tovmasyan, Artak, Bueno-Janice, Jacqueline C., Jaramillo, Melba C., Sampaio, Romulo S., Reboucas, Julio S., Kyui, Natalia, Benov, Ludmil, Deng, Brian, Huang, Ting-Ting, Tome, Margaret E., Spasojevic, Ivan, Batinic-Haberle, Ines
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2018
Assuntos:
Forum Original Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157436/
https://ncbi.nlm.nih.gov/pubmed/29390861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2017.7218
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