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Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo

Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range of cells and organisms. There is, however, considerable variation in the efficiency of cleavage and outcomes at different genomic targets, even within the same cell type. Some of this variability is likely due to...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Yarrington, Robert M., Verma, Surbhi, Schwartz, Shaina, Trautman, Jonathan K., Carroll, Dana
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156633/
https://ncbi.nlm.nih.gov/pubmed/30201707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810062115
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