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Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo

Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range of cells and organisms. There is, however, considerable variation in the efficiency of cleavage and outcomes at different genomic targets, even within the same cell type. Some of this variability is likely due to...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Yarrington, Robert M., Verma, Surbhi, Schwartz, Shaina, Trautman, Jonathan K., Carroll, Dana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156633/
https://ncbi.nlm.nih.gov/pubmed/30201707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810062115
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