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Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long‐lived animals

Disruption of mitochondrial metabolism and loss of mitochondrial DNA (mtDNA) integrity are widely considered as evolutionarily conserved (public) mechanisms of aging (López‐Otín et al., Cell, 153, 2013 and 1194). Human aging is associated with loss in skeletal muscle mass and function (Sarcopenia),...

詳細記述

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書誌詳細
出版年:Aging Cell
主要な著者: Lakshmanan, Lakshmi Narayanan, Yee, Zhuangli, Ng, Li Fang, Gunawan, Rudiyanto, Halliwell, Barry, Gruber, Jan
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156498/
https://ncbi.nlm.nih.gov/pubmed/30043489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12814
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