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Role of Direct Repeat and Stem-Loop Motifs in mtDNA Deletions: Cause or Coincidence?

Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and aging related conditions, such as sarcopenia and neuro-degeneration. While the precise molecular mechanism of deletion formation in mtDNA is still not completely understood, genome motifs such as direct repe...

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Detalhes bibliográficos
Main Authors: Lakshmanan, Lakshmi Narayanan, Gruber, Jan, Halliwell, Barry, Gunawan, Rudiyanto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329436/
https://ncbi.nlm.nih.gov/pubmed/22529999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035271
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