Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long‐lived animals

Disruption of mitochondrial metabolism and loss of mitochondrial DNA (mtDNA) integrity are widely considered as evolutionarily conserved (public) mechanisms of aging (López‐Otín et al., Cell, 153, 2013 and 1194). Human aging is associated with loss in skeletal muscle mass and function (Sarcopenia),...

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Bibliografske podrobnosti
izdano v:Aging Cell
Main Authors: Lakshmanan, Lakshmi Narayanan, Yee, Zhuangli, Ng, Li Fang, Gunawan, Rudiyanto, Halliwell, Barry, Gruber, Jan
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156498/
https://ncbi.nlm.nih.gov/pubmed/30043489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12814
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