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Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long‐lived animals

Disruption of mitochondrial metabolism and loss of mitochondrial DNA (mtDNA) integrity are widely considered as evolutionarily conserved (public) mechanisms of aging (López‐Otín et al., Cell, 153, 2013 and 1194). Human aging is associated with loss in skeletal muscle mass and function (Sarcopenia),...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Aging Cell
Egile Nagusiak: Lakshmanan, Lakshmi Narayanan, Yee, Zhuangli, Ng, Li Fang, Gunawan, Rudiyanto, Halliwell, Barry, Gruber, Jan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156498/
https://ncbi.nlm.nih.gov/pubmed/30043489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12814
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