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Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity

How tumor microenvironmental forces shape plasticity of cancer cell morphology is poorly understood. Here, we conduct automated histology image and spatial statistical analyses in 514 high grade serous ovarian samples to define cancer morphological diversification within the spatial context of the m...

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Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Heindl, Andreas, Khan, Adnan Mujahid, Rodrigues, Daniel Nava, Eason, Katherine, Sadanandam, Anguraj, Orbegoso, Cecilia, Punta, Marco, Sottoriva, Andrea, Lise, Stefano, Banerjee, Susana, Yuan, Yinyin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156340/
https://ncbi.nlm.nih.gov/pubmed/30254278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06130-3
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