Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Alzheimer's disease (AD) is an intractable progressive neurodegenerative disease characterized by cognitive decline and dementia. An inflammatory neurodegenerative pathway, involving Caspase-1 activation, is associated with human age-dependent cognitive impairment and several classical AD brain...

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Vydáno v:Nat Commun
Hlavní autoři: Flores, Joseph, Noël, Anastasia, Foveau, Bénédicte, Lynham, Jeffrey, Lecrux, Clotilde, LeBlanc, Andréa C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156230/
https://ncbi.nlm.nih.gov/pubmed/30254377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06449-x
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