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Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model

Alzheimer's disease (AD) is an intractable progressive neurodegenerative disease characterized by cognitive decline and dementia. An inflammatory neurodegenerative pathway, involving Caspase-1 activation, is associated with human age-dependent cognitive impairment and several classical AD brain...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Flores, Joseph, Noël, Anastasia, Foveau, Bénédicte, Lynham, Jeffrey, Lecrux, Clotilde, LeBlanc, Andréa C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156230/
https://ncbi.nlm.nih.gov/pubmed/30254377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06449-x
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