Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

BACKGROUND: The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most Caspase-6 inhibitors have been exclu...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Pakavathkumar, Prateep, Noël, Anastasia, Lecrux, Clotilde, Tubeleviciute-Aydin, Agne, Hamel, Edith, Ahlfors, Jan-Eric, LeBlanc, Andrea C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5329948/
https://ncbi.nlm.nih.gov/pubmed/28241839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0166-z
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