Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

Neuronal active Caspase-6 (Casp6) is associated with Alzheimer disease (AD), cognitive impairment, and axonal degeneration. Caspase-1 (Casp1) can activate Casp6 but the expression and functionality of Casp1-activating inflammasomes has not been well-defined in human neurons. Here, we show that prima...

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Опубликовано в: :Cell Death Differ
Главные авторы: Kaushal, V, Dye, R, Pakavathkumar, P, Foveau, B, Flores, J, Hyman, B, Ghetti, B, Koller, B H, LeBlanc, A C
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563782/
https://ncbi.nlm.nih.gov/pubmed/25744023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.16
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