Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

Activated Caspase-6 (Casp6) is associated with age-dependent cognitive impairment and Alzheimer disease (AD). Mice expressing human Caspase-6 in hippocampal CA1 neurons develop age-dependent cognitive deficits, neurodegeneration and neuroinflammation. This study assessed if methylene blue (MB), a ph...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Zhou, Libin, Flores, Joseph, Noël, Anastasia, Beauchet, Olivier, Sjöström, P. Jesper, LeBlanc, Andrea C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6915996/
https://ncbi.nlm.nih.gov/pubmed/31843022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0856-6
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