LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

The linear ubiquitin chain assembly complex (LUBAC), composed of HOIP, HOIL-1 and SHARPIN, is required for optimal TNF-mediated gene activation and to prevent cell death induced by TNF. Here, we demonstrate that keratinocyte-specific deletion of HOIP or HOIL-1 (E-KO) results in severe dermatitis cau...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Taraborrelli, Lucia, Peltzer, Nieves, Montinaro, Antonella, Kupka, Sebastian, Rieser, Eva, Hartwig, Torsten, Sarr, Aida, Darding, Maurice, Draber, Peter, Haas, Tobias L., Akarca, Ayse, Marafioti, Teresa, Pasparakis, Manolis, Bertin, John, Gough, Peter J., Bouillet, Philippe, Strasser, Andreas, Leverkus, Martin, Silke, John, Walczak, Henning
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156229/
https://ncbi.nlm.nih.gov/pubmed/30254289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06155-8
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