LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases CYLD and A20, but not OTULIN, are recruited to the TNFR1- and NOD2...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Draber, Peter, Kupka, Sebastian, Reichert, Matthias, Draberova, Helena, Lafont, Elodie, de Miguel, Diego, Spilgies, Lisanne, Surinova, Silvia, Taraborrelli, Lucia, Hartwig, Torsten, Rieser, Eva, Martino, Luigi, Rittinger, Katrin, Walczak, Henning
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688036/
https://ncbi.nlm.nih.gov/pubmed/26670046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.009
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