SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

Recruitment of the deubiquitinase CYLD to signaling complexes is mediated by its interaction with HOIP, the catalytically active component of the linear ubiquitin chain assembly complex (LUBAC). Here, we identify SPATA2 as a constitutive direct binding partner of HOIP that bridges the interaction be...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kupka, Sebastian, De Miguel, Diego, Draber, Peter, Martino, Luigi, Surinova, Silvia, Rittinger, Katrin, Walczak, Henning
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009064/
https://ncbi.nlm.nih.gov/pubmed/27545878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.086
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